MMPIP hydrochloride (50 MG)
货号：
2963/50 基本售价：
10489.5 元 规格：
50 mg
产品信息
概述| 货号 | 2963/50 |
| 别名 | 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 369.8 |
| 分子式 | C19H15N3O3.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 479077-02-6 |
| 参考文献 | Suzukiet al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147. PMID: 17609420. |
