| 货号 | 3533/50 |
| 别名 | N-(6-Methyl-2-benzothiazolyl)-2-[(3 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 466.6 |
| 分子式 | C22H18N4O2S3 |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming |
| CAS号 | 686770-61-6 |
| 参考文献 | Lianet al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U S A 109 E1848. PMID: 22645348. ten Bergeet al (2011) Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat.Cell.Biol. 13 1070. PMID: 21841791. Chenet al (2009) Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. Nature Chem.Biol. 5 100. PMID: 19125156. |