| 货号 | 1813/50 |
| 别名 | 3-[1,3-Dihydro-3-(hydroxyimino)-2H- |
| 供应商 | Tocris |
| 生物活性 | Protein kinase inhibitor; inhibits cyclin-dependent kinases (IC50 = 0.18 - 3.33 μM) and GSK-3β(IC50 = 0.19 μM). Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 277.28 |
| 分子式 | C16H11N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 160807-49-8 |
| 参考文献 | Bainet al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346. Leclercet al (2001) Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. J.Biol.Chem. 276 251. PMID: 11013232. Hoesselet al (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat.Cell.Biol. 1 60. PMID: 10559866. |