| 货号 | 3530/50 |
| 别名 | 4-(Diphenylmethoxy)-1-(3-2H-tetrazo |
| 供应商 | Tocris |
| 生物活性 | Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 377.48 |
| 分子式 | C22H27N5O |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| CAS号 | 162641-16-9 |
| 参考文献 | Aritakeet al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277. PMID: 16547010. Mohriet al (2006) Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383. PMID: 16624958. Matsushitaet al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11. PMID: 9804057. |