| 货号 | 1381/50 |
| 别名 | 3-(3,5-Dibromo-4-hydroxy-benzyliden |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 520.94 |
| 分子式 | C15H8Br2INO2 |
| 可溶性/溶解性 | Soluble to 1 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 220904-83-6 |
| 参考文献 | Chenet al (2008) Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. J.Neurochem. 105 1300. PMID: 18194435. Breslinet al (2003) VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am.J.Physiol.Heart Circ.Physiol. 284 H92. PMID: 12388327. Vargaet al (2002) Involvement of Raf-1 in chronic delta-opioid receptor agonist-mediated adenylyl cyclase superactivation. Eur.J.Pharmacol. 451 101. PMID: 12223234. Lackeyet al (2000) The discovery of potent cRaf1 kinase inhibitors. Bioorg.Med.Chem.Lett. 10 223. PMID: 10698440. |