| 货号 | 5485/50 |
| 别名 | N-2-Naphthalenyl-2-[(3,5-dibromo-2, |
| 供应商 | Tocris |
| 生物活性 | Reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 493.15 |
| 分子式 | C19H15Br2N3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Norimatsuet al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042. PMID: 22923500. Muanprasatet al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125. PMID: 15277574. |