| 货号 | 4554/50 |
| 别名 | 2-[4-[[4-Hydroxy-3-(1-methylethyl)p |
| 供应商 | Tocris |
| 生物活性 | Thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively). Displays 5- and 100-fold greater potency than the endogenous agonist T3in vitro at TRα1 and TRβ1 receptors respectively. Promotes reverse cholesterol transport in chow- and fat-fed mice. Induces proliferation of hepatocytes and pancreatic acinar cells in rats independent of prior tissue injury. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 328.4 |
| 分子式 | C20H24O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Columbanoet al (2006) The thyroid hormone receptor-β agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 147 3211. PMID: 16574785. Johanssonet al (2005) Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc.Natl.Acad.Sci. U S A 102 10297. PMID: 16006512. Chielliniet al (1998) A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chem.Biol. 5 299. PMID: 9653548. |