| 货号 | 2348/50 |
| 别名 | 4,6-Dichloro-3-[(1E)-3-oxo-3-(pheny |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Orally bioavailable and active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 397.19 |
| 分子式 | C18H11Cl2N2O3Na |
| 可溶性/溶解性 | Soluble to 40 mM in DMSO |
| CAS号 | 153436-22-7 |
| 参考文献 | Kajbafet al (2003) Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog. Xenobiotica. 33 415. PMID: 12745876. Mugnainiet al (2000) Receptor binding characteristics of the novel NMDA receptor glycine site antagonist [3H]GV150526A in rat cerebral cortical membranes. Eur.J.Pharmacol. 391 233. PMID: 10729363. Di Fabioet al (1997) Substituted indole-2-carboxylates as in vivo potent antagonists acting at the strychnine-insensitive glycine binding site. J.Med.Chem. 40 841. PMID: 9083472. |