| 货号 | 2007/50 |
| 别名 | (6α,11β,16α,17α)-6,9-Difluoro-11-hydrox |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 500.57 |
| 分子式 | C25H31F3O5S |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 80474-14-2 |
| 参考文献 | Panet al (2012) Potentiation of the Kv1 family K+ channel by cortisone analogues. ACS Chem.Biol. 7 1641. PMID: 22803826. Zhanget al (2000) Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone. Eur.J.Pharmacol. 406 325. PMID: 11040338. Smith and Kreutner (1998) In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch. 48956. Johnson (1995) The anti-inflammatory profile of fluticasone propionate. Allergy 50 11. PMID: 7604948. |