| 货号 | 1399/50 |
| 别名 | N-[1-(Phenylmethyl)-4(1H)-quinoliny |
| 供应商 | Tocris |
| 生物活性 | Potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM) . Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 340.89 |
| 分子式 | C21H24N2.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| CAS号 | 185855-91-8 |
| 参考文献 | Jageret al (1998) Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 506 291. PMID: 9490854. Nguyenet al (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol.Pharmacol. 50 1672. PMID: 8967992. |