DYn-2
货号：
11220-25mg 基本售价：
10290.0 元 规格：
25 mg
产品信息
概述| 货号 | 11220-25mg |
| 描述 | Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH).1 Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells.2 DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications.2 The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.3 |
| 别名 | Click Tag™ DYn-2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kettenhofen, N.J. and Wood, M.J. Formation, reactivity and detection of protein sulfenic acids. Chemical Research in Toxicology 23(11), 1633-1646 (2010).
2.Paulsen, C.E.,Truong, T.H.,Garcia, F.J., et al. Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity. Nature Chemical Biology 8, 57-64 (2012).
3.Charron, G.,Zhang, M.M.,Yount, J.S., et al. Robust fluorescent detection of protein fatty-acylation with chemical reporters. Journal of the American Chemical Society 131, 4967-4975 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 178.2 |
| 分子式 | C11H14O2 |
| CAS号 | 1354630-46-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
