Vacquinol-1
货号：
16321-25mg 基本售价：
10234.0 元 规格：
25 mg
产品信息
概述| 货号 | 16321-25mg |
| 描述 | Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture.1 A key effector of vacquinols is MAPK kinase 4 (MKK4).1 Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.1 It induces ATP depletion in glioblastoma cells (IC50 = 3.14 µM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.1 Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics.1 Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.1 |
| 别名 | NSC 13316; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kitambi, S.S.,Toledo, E.M.,Usoskin, D., et al. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule. Cell 157(2), 313-328 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 352.9 |
| 分子式 | C21H21ClN2O |
| CAS号 | 5428-80-8 |
| 稳定性 | ≥ 2 years |
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