| 货号 | 4719/50 |
| 别名 | N-Cyclopropyl-N-(4-methyl-2-thiazol |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 61 nM); displays >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 382.5 |
| 分子式 | C19H18N4OS2< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming |
| 参考文献 | Sivakumaranet al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J.Neurosci. 35 8291. PMID: 26019342. Delpireet al (2012) Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg.Med.Chem.Lett. 22 4532. PMID: 22727639. |