| 货号 | 3657/50 |
| 别名 | 3--Phenyl-N-(2,2,2-trichloro-1-(((( |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α(eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 463.21 |
| 分子式 | C18H15Cl4N3OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 1164470-53-4 |
| 参考文献 | Ravenet al (2008) PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J.Biol.Chem. 283 3097. PMID: 18063576. Baltizet al (2007) The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53. J.Biol.Chem. 282 31675. PMID: 17785458. Costa-Mattioliet al (2007) eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129 195. PMID: 17418795. |