| 货号 | 4951/50 |
| 别名 | 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4- |
| 供应商 | Tocris |
| 生物活性 | Selectiveσ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 441.43 |
| 分子式 | C23H32N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 20 mM in DMSO |
| 参考文献 | Tagashiraet al (2013) Stimulation of s1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy. Biochim.Biophys.Acta 1830 3082. PMID: 23298811. Ruscheret al (2011) The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134 732. PMID: 21278085. Leveret al(2006)σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse 59 350. PMID: 16463398. Matsunoet al (1996) Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur.J.Pharmacol. 306 271. PMID: 8813641. |