| 货号 | 4604/50 |
| 别名 | 1-(3,4-Dihydro-7-hydroxy-6-methoxy- |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of MMP-3 expression (IC50 = 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 235.28 |
| 分子式 | C13H17NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH |
| 参考文献 | Sonet al (2012) A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP. Br.J.Pharmacol. 165 2213. PMID: 21951056. Seoet al (2008) Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells. Eur.J.Med.Chem. 43 1160. PMID: 17980460. |