15-keto Prostaglandin E2
货号：
14720-10mg 基本售价：
10192.0 元 规格：
10 mg
产品信息
概述| 货号 | 14720-10mg |
| 描述 | 15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy PGDH.1,2In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2(Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).3 |
| 别名 | 15-keto PGE2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hamberg, M. and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971).
2.Mak, O.T.,Liu, Y. and Tai, H.H. Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. Biochimica et Biophysica Acta 1035, 190-196 (1990).
3.Nishigaki, N.,Negishi, M. and Ichikawa, A. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Molecular Pharmacology 50, 1031-1037 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 350.5 |
| 分子式 | C20H30O5 |
| CAS号 | 26441-05-4 |
| 稳定性 | ≥ 2 years |
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