| 货号 | 13299-25mg |
| 描述 | Bisindolylmaleimide IV (BIM IV) is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM.1,2,3,4 BIM IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Item No. 81590). However, BIM IV also inhibits protein kinase A with IC50 values ranging from 2 to 11.8 µM.1,2 |
| 别名 | Arcyriarubin A;BIM IV; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Davis, P.D.,Hill, C.H.,Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. Journal of Medicinal Chemistry 35, 177-184 (1992). 2.Toullec, D.,Pianetti, P.,Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. The Journal of Biological Chemisty 266(24), 15771-15781 (1991). 3.Fabre, S. and Prudhomme, M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorganic & Medicinal Chemistry 1(3), 193-196 (1993). 4.Lazareno, S.,Popham, A. and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. European Journal of Pharmacology 360, 281-284 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.3 |
| 分子式 | C20H13N3O2 |
| CAS号 | 119139-23-0 |
| 稳定性 | ≥ 2 years |
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