M8 B hydrochloride (50 MG)
货号：
5324/50 基本售价：
10043.4 元 规格：
50 mg
产品信息
概述| 货号 | 5324/50 |
| 别名 | N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamidehydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro(IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 432.96 |
| 分子式 | C22H24N2O3 |
| 可溶性/溶解性 | Soluble to 10 mM in water with sonication and to 100 mM in DMSO |
| 参考文献 | Almeidaet al (2012) Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 32 2086. PMID: 22323721. |
