| 货号 | 4872/50 |
| 别名 | 4-[Bis(1,3-benzodioxol-5-yl)hydroxy |
| 供应商 | Tocris |
| 生物活性 | Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 549.42 |
| 分子式 | C24H21F6NO7< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Changet al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579. PMID: 22542104. Uedaet al (2012) Discrimination between two endocannabinoids. Chem.Biol. 19 545. PMID: 22633404. |