| 货号 | 4199/50 |
| 别名 | N-(Tricyclo[3.3.1.13,7]dec-1-ylmeth |
| 供应商 | Tocris |
| 生物活性 | Voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 412.25 |
| 分子式 | C16H30N2.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 50 mM in DMSO |
| 参考文献 | Tikhonovet al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265. PMID: 10694232. Magazaniket al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655. PMID: 9457643. |