| 货号 | 3759/50 |
| 别名 | 6-Methyleneandrosta-1,4-diene-3,17- |
| 供应商 | Tocris |
| 生物活性 | Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 296.4 |
| 分子式 | C20H24O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| CAS号 | 107868-30-4 |
| 参考文献 | Milleret al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829. PMID: 18695261. Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281. PMID: 17079446. Gosset al (2004) The steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized rats. Bone 34 384. PMID: 15003786. di Salleet al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43137. |