| 货号 | 4417/50 |
| 别名 | N2,N4-Bis(phenylmethyl)-2,4-quinazo |
| 供应商 | Tocris |
| 生物活性 | Selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 340.42 |
| 分子式 | C22H20N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Chouet al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834. PMID: 21383145. Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091. PMID: 21606684. |