| 货号 | 2932/50 |
| 别名 | 3-(2-Chlorophenyl)-2-[2-[6-[(diethy |
| 供应商 | Tocris |
| 生物活性 | Selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 499.41 |
| 分子式 | C26H24ClFN4O |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 100 mM in DMSO |
| CAS号 | 199655-36-2 |
| 参考文献 | Welchet al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165. PMID: 18687344. Mennitiet al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171. PMID: 12511770. Lazaroet al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143. PMID: 11804610. |