| 货号 | 3023/50 |
| 别名 | N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4 |
| 供应商 | Tocris |
| 生物活性 | p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 435.39 |
| 分子式 | C22H26N4O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 259199-65-0 |
| 参考文献 | Demmaet al (2004) CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73. J.Biol.Chem. 279 45887. PMID: 15308639. Wischhusenet al (2003) CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene 22 8233. PMID: 14614447. Fosteret al (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286 2507. PMID: 10617466. |