| 货号 | 3868/50 |
| 别名 | 6-(2-Fluorophenyl)-1,3-dioxolo[4,5- |
| 供应商 | Tocris |
| 生物活性 | Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitroandin vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 283.25 |
| 分子式 | C16H10FNO3 |
| 可溶性/溶解性 | Soluble to 25 mM in water |
| CAS号 | 154554-41-3 |
| 参考文献 | Tsaiet al (2010) CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J.Biol.Chem. 285 5497. PMID: 20007968. Wanget al (2008) CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitroandin vivo. Mol.Cancer.Ther. 7 350. PMID: 18281518. |