| 货号 | 3194/50 |
| 别名 | (2'Z,3'E)-6-Bromoindirubin-3'-oxime; 6BIO |
| 供应商 | Tocris |
| 生物活性 | Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes. Negative control available (Cat. No. 3873). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 356.17 |
| 分子式 | C16H10BrN3O6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 667463-62-9 |
| 参考文献 | Tsenget al (2006) The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem.Biol. 13 957. PMID: 16984885. Polychronopouloset al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibtors of glycogen synthase kinase-3 and cyclin dependent kinases. J.Med.Chem. 47 935. PMID: 14761195. Meijeret al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633. |