| 货号 | 3875/50 |
| 别名 | 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1- |
| 供应商 | Tocris |
| 生物活性 | Orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 372.89 |
| 分子式 | C20H25ClN4O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 40 mM in ethanol |
| CAS号 | 393514-24-4 |
| 参考文献 | Pomoniset al(2003)N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain. J.Pharmacol.Exp.Ther. 306 387. PMID: 12721336. Valenzanoet al(2003)N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic properties. J.Pharmacol.Exp.Ther. 306 377. PMID: 12721338. |