| 货号 | 4372/50 |
| 别名 | Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide |
| 供应商 | Tocris |
| 生物活性 | Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 290.97 |
| 分子式 | C8H11BN2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming |
| 参考文献 | Longoet al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879. PMID: 26029857. Smithet al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9819. |