| 货号 | 3737/50 |
| 别名 | (3aR*,12bR*)-5-Chloro-2,3,3a,12b-te |
| 供应商 | Tocris |
| 生物活性 | Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pKi values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, 5-HT7, D1, D2L, D2S, D3, D4,α1A,α2A,α2B,α2C, H1 and H2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 401.84 |
| 分子式 | C17H16CINO.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 65576-45-6 |
| 参考文献 | Marstonet al (2009) Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 206699. Meltzeret al (2009) Asenapine. Nat.Rev.Drug Discov. 8 843. PMID: 19876039. Shahidet al (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 23 65. PMID: 18308814. |