| 货号 | 1637/50 |
| 别名 | (2R,4R)-1-[(2S)-5-[(aminoiminomethy |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 508.63 |
| 分子式 | C23H36N6O5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl |
| CAS号 | 74863-84-6 |
| 参考文献 | Janget al (1990) Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81 219. PMID: 2297828. Fitzgerald and Fitzgerald (1989) Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA 867585. Kikumotoet al (1984) Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23 85. PMID: 6691968. |