| 货号 | 2098/50 |
| 别名 | 1-[(3,4-Dichlorophenyl)methyl]-1H-i |
| 供应商 | Tocris |
| 生物活性 | Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 306.14 |
| 分子式 | C15H9Cl2NO2 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 79183-19-0 |
| 参考文献 | Alavianet al (2009) Elevtaed p75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 4 11. PMID: 19291307. Jayaraman and Pike (2009) Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. J.Neuroendocrinol. 21 77. PMID: 19094096. Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.USA 1007533. |