| 货号 | 1117/50 |
| 别名 | N-(Piperidin-1-yl)-5-(4-iodophenyl) |
| 供应商 | Tocris |
| 生物活性 | Potent CB1 receptor antagonist (IC50 = 8 nM, Ki = 7.49 nM) that displays 306-fold selectivity over CB2 receptors. Also potent GPR55 agonist (EC50 = 39 nM). Also available in a fluorescent form (Cat. No. 2540). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 555.24 |
| 分子式 | C22H21Cl2IN4O |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 183232-66-8 |
| 参考文献 | Ryberget al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302. Pertwee (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci. 76 1307. PMID: 15670612. Lanet al (1999) Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J.Med.Chem. 42 769. PMID: 10052983. Gatleyet al (1997) Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci. 61 191. PMID: 9335234. Gatleyet al(1996)125I-labeled AM 251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur.J.Pharmacol. 307 331. PMID: 8836622. |