| 货号 | 0998/50 |
| 别名 | 4-Imino-1-(2-phenylphenoxy)-4-piper |
| 供应商 | Tocris |
| 生物活性 | A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B(hamster),α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 374.91 |
| 分子式 | C21H26N2O2.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water |
| CAS号 | 179388-65-9 |
| 参考文献 | Eltzeet al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265. PMID: 11275009. Saussyet al (1996) Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136. PMID: 8764344. Kinget al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20526. |