| 货号 | 3826/50 |
| 别名 | 7,8-Dihydroxy-2-phenyl-4H-1-benzopy |
| 供应商 | Tocris |
| 生物活性 | Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitroandin vivo. Exhibits neuroprotective effects in an HD mouse model. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 254.24 |
| 分子式 | C15H10O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH |
| CAS号 | 38183-03-8 |
| 参考文献 | Jianget al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462. PMID: 23446639. Anderoet al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399. PMID: 21136519. Janget al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107268. |