| 货号 | 1253/50 |
| 别名 | (S)-N-tert-Butyl-3-(4-(2-methoxyphe |
| 供应商 | Tocris |
| 生物活性 | Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B,1C,2,α1,α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 468.47 |
| 分子式 | C24H33N3O2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming and to 10 mM in water with sonication |
| CAS号 | 133025-23-7 |
| 参考文献 | Rodgers and Cole (1994) Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 261 321. PMID: 7813555. Cliffeet al (1993) (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J.Med.Chem. 36 1509. PMID: 8496920. Fletcheret al (1993) WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur.J.Pharmacol. 237 283. PMID: 8365456. Fletcheret al (1993) Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 14 41. PMID: 8122313. |