Epothilone B
货号：
10924-10mg 基本售价：
9856.0 元 规格：
10 mg
产品信息
概述| 货号 | 10924-10mg |
| 描述 | Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.1,2 It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively).1 Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.3 |
| 别名 | Epo B; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bollag, D.M.,McQueney, P.A.,Zhu, J., et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Research 55(11), 2325-2333 (1995).
2.Kowalski, R.J.,Giannakakou, P., and Hamel, E. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). The Journal of Biological Chemisty 272(4), 2534-2541 (1997).
3.Goodin, S.,Kane, M.P., and Rubin, E.H. Epothilones: Mechanism of action and biologic activity. Journal of Clinical Oncology 22(10), 2015-2025 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 507.7 |
| 分子式 | C27H41NO6S |
| CAS号 | 152044-54-7 |
| 稳定性 | ≥ 2 years |
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