Trichostatin A
货号：
89730-10mg 基本售价：
9800.0 元 规格：
10 mg
产品信息
概述| 货号 | 89730-10mg |
| 描述 | Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM.1 Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.2 |
| 别名 | TSA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hoshikawa, Y.,Kwon, H.J.,Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Experimental Cell Research 214, 189-197 (1994).
2.Taunton, J.,Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 302.4 |
| 分子式 | C17H22N2O3 |
| CAS号 | 58880-19-6 |
| 稳定性 | ≥ 2 years |
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