| 货号 | 18116-50mg |
| 描述 | Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation.1,2,3,4 SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM).5 SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6.5 This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tang, B.L., and Chua, C.E.L. SIRT2, tubulin deacetylation, and oligodendroglia differentiation. Cell Motility and the Cytoskeleton 65, 179-182 (2008). 2.North, B.J.,Marshall, B.L.,Borra, M.T., et al. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Molecular Cell 11, 437-444 (2003). 3.Dryden, S.C.,Nahhas, F.A.,Nowak, J.E., et al. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Molecular and Cellular Biology 23(9), 3173-3185 (2003). 4.de Oliveira, R.M.,Sarkander, J.,Kazantsev, A.G., et al. SIRT2 as a therapeutic target for age-related disorders. Front.Pharmacol. 3(82), (2012). 5.Rumpf, T.,Schiedel, M.,Karaman, B., et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6, (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 420.5 |
| 分子式 | C22H20N4OS2 |
| CAS号 | 709002-46-0 |
| 稳定性 | ≥ 2 years |
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