Erastin
货号：
17754-50mg 基本售价：
9800.0 元 规格：
50 mg
产品信息
概述| 货号 | 17754-50mg |
| 描述 | Erastin, named for eradicator of RASandST-expressing cells, is an irreversible antitumor agent that selectively kills cells expressing the small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 µg/ml).1 It produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel gating, allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dolma, S.,Lessnick, S.L.,Hahn, W.C., et al. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3(3), 285-296 (2003).
2.Yagoda, N.,von Rechenberg, M.,Zaganjor, E., et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447(7146), 864-868 (2007).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 547.1 |
| 分子式 | C30H31ClN4O4 |
| CAS号 | 571203-78-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
