| 货号 | 14325-25g |
| 描述 | 2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis.1,2 This results in the depletion in cellular ATP, the inhibition of protein glycosylation, and the disruption of ER quality control by inducing the unfolded protein response.1 2-deoxy-D-Glucose has been shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models.3,2,4 |
| 别名 | Ba 2758;NSC 15193; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kang, H.T. and Hwang, E.S. 2-Deoxyglucose: An anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sciences 78(12), 1392-1399 (2006). 2.Zhang, X.D.,Deslandes, E.,Villedieu, M., et al. Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro. Anticancer Research 26, 3561-3566 (2006). 3.Kurtoglu, M.,Gao, N.,Shang, J., et al. Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Molecular Cancer Therapeutics 6(11), 3049-3058 (2007). 4.Ralser, M.,Wamelink, M.M.,Struys, E.A., et al. A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proceedings of the National Academy of Sciences of the United States of America 105(46), 17807-17811 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 164.2 |
| 分子式 | C6H12O5 |
| CAS号 | 154-17-6 |
| 稳定性 | ≥ 2 years |
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