YK-4-279
货号：
13661-50mg 基本售价：
9800.0 元 规格：
50 mg
产品信息
概述| 货号 | 13661-50mg |
| 描述 | ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 µM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Erkizan, H.V.,Kong, Y.,Merchant, M., et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing’s sarcoma. Nature Medicine 15(7), 750-756 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 366.2 |
| 分子式 | C17H13Cl2NO4 |
| CAS号 | 1037184-44-3 |
| 稳定性 | ≥ 2 years |
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