| 货号 | 13623-1g |
| 描述 | Topiramate is a sugar sulfamate that exhibits potent anticonvulsant activity. It completely blocks seizures (ED50 = 39 mg/kg when given orally) in mice in the maximal electroshock seizure test.1,2 This effect is sustained for over eight hours.1,2 In the rotoreel test of neurotoxicity, topiramate has a peak neurotoxic dose ED50 value of 407 mg/kg in mice at one hour.1 It is virtually inactive against seizures caused by pentylenetetrazol, bicuculline, picrotoxin, and strychnine. It does not bind to norepinephrine, serotonin, γ-amino butyric acid, muscarinic, or dopamine receptors.1,2 The drug form of Topiramate, Topamax®, is used alone or with other medications to treat seizures associated with epilepsy and to prevent migraine headaches.3,4 |
| 别名 | Epitomax;McN 4853;RWJ 17021;TPM;Topamax®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maryanoff, B.E.,Nortey, S.O.,Gardocki, J.F., et al. Anticonvulsant O-alkyl sulfamates. 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate and related compounds. Journal of Medicinal Chemistry 30, 880-887 (1987). 2.Shank, R.P.,Gardocki, J.F.,Vaught, J.L., et al. Topiramate: Preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 35(2), 450-460 (1994). 3.Ben-Menachem, E.,Sander, J.W.,Stefan, H., et al. Topiramate monotherapy in the treatment of newly or recently diagnosed epilepsy. Clinical Therapeutics 30(7), 1180-1195 (2008). 4.Ruiz, L., and Ferrandi, D. Topiramate in migraine progression. Journal of Headache and Pain 10, 419-422 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 339.4 |
| 分子式 | C12H21NO8S |
| CAS号 | 97240-79-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |