BAW 2881
货号：
18910-25mg 基本售价：
9786.0 元 规格：
25 mg
产品信息
概述| 货号 | 18910-25mg |
| 描述 | BAW 2881 is a vascular endothelial growth factor receptor (VEGFR) inhibitor (IC50s = 0.82, 0.037, and 0.42 µM for hVEGFR1, 2, and 3, respectively).1 It inhibits Tie2 and RET with IC50 values of 0.65 and 0.41 µM, respectively, but demonstrates IC50 values great than 10 µM toward a large panel of additional kinases.1 BAW 2881 was shown to block VEGF-A-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells and lymphatic endothelial cells in vitro.1 In a mouse model of psoriasis, both oral and topical administration of BAW 2881 reduced psoriasis-like inflammation in ear skin.1 Topical application of BAW 2881 also reduced VEGF-A-induced vascular permeability and inhibited contact hypersensitivity reactions and UV-B-induced erythema in the skin of domestic pigs.1 |
| 别名 | NVP-BAW 2881; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Halin, C.,Fahrngruber, H.,Meingassner, J.G., et al. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am.J.Pathol. 173(1), 265-277 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 424.4 |
| 分子式 | C22H15F3N4O2 |
| CAS号 | 861875-60-7 |
| 稳定性 | ≥ 2 years |
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