Eggmanone ( )
货号：
5695/50 基本售价：
9745.9 元 规格：
50 mg
产品信息
概述| 货号 | 5695/50 |
| 别名 | 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1andPtc1. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 416.58 |
| 分子式 | C20H20N2O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Williamset al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43. PMID: 25818300. |
