| 货号 | 17143-5mg |
| 描述 | Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.1 8-pCPT-2-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM).2 It is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP.2,3 8-pCPT-2-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA.3 It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.1,4,5,6 |
| 别名 | 8-CPT-2Me-cAMP;8-pCPT-cAMP;8-pCPT-2′-O-Me-cAMP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Breckler, M.,Berthouze, M.,Laurent, A.C., et al. Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications. Cellular Signalling 23(8), 1257-1266 (2011). 2.Rehmann, H.,Schwede, F.,Doskeland, S.O., et al. Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. The Journal of Biological Chemisty 278(40), 38548-38556 (2003). 3.Christensen, A.E.,Selheim, F.,de Rooij, J., et al. cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. The Journal of Biological Chemisty 278(37), 35394-35402 (2003). 4.Kang, G.,Chepurny, O.G.,Malester, B., et al. cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cells. Journal of Physiology 573(Pt 3), 595-609 (2006). 5.Eid, A.H.,Chotani, M.A.,Mitra, S., et al. Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors. American Journal of Physiology.Heart and Circulatory Physiology 295(1), H266-H272 (2008). 6.Quan, Y.,Jiang, J., and Dingledine, R. EP2 receptor signaling pathways regulate classical activation of microglia. The Journal of Biological Chemisty 288(13), 9293-9302 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 507.8 |
| 分子式 | C17H16N5O6ClPS • Na |
| CAS号 | 634207-53-7 |
| 稳定性 | ≥ 2 years |
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