| 货号 | 19449-5mg |
| 描述 | Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium.1 It potentiates the cytotoxicity of vincristine (Item No. 11764), an anti-cancer alkaloid known to be exported from cells by P-glycoprotein.1,2 Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil (Item No. 14288), a P-glycoprotein inhibitor.3,4 The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.3 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kamei, H.,Oka, M.,Hamagishi, Y., et al. Piperafizines A and B, potentiators of cytotoxicity of vincristine. J.Antibiot.(Tokyo) 43(8), 1018-1020 (1990). 2.van Tellingen, O.,Buckle, T.,Jonker, J.W., et al. P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo. British Journal of Cancer 89(9), 1776-1782 (2003). 3.Ogasawara, M.,Hasegawa, M.,Hamagishi, Y., et al. Potentiation of vincristine cytotoxicity by rubiginone B1 and piperafizine A in human Moser and K562 cells--mode of action. J.Antibiot.(Tokyo) 45(1), 129-132 (1992). 4.Chan, H.S.L.,Haddad, G.,Thorner, P.S., et al. P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma. New England Journal of Medicine 325(23), 1608-1614 (1991). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 304.3 |
| 分子式 | C19H16N2O2 |
| CAS号 | 130603-59-7 |
| 稳定性 | ≥ 2 years |
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