| 货号 | 17118-500mg |
| 描述 | Niclosamide (Item No. 10649) is an antihelminthic compound that affects mitochondrial metabolism in parasitic worms.1,2 It specifically inhibits the signal transducer and activator of transcription 3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mTORC1 signaling (complete inhibition of S6K phosphorylation at 3 μM).2,3 Niclosamide ethanolamine is a more water soluble, salt version of niclosamide that has been used to increase energy expenditure and lipid metabolism in mice.4 At 125 mg/kg/day, niclosamide ethanolamine prevented high-fat diet-induced hepatic steatosis and insulin resistance and improved glycemic control in db/dbmice.4 |
| 别名 | Bayluscide;NEN; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pampori, N.A.,Singh, G., and Srivastava, V.M.L. Energy metabolism in Cotugnia digonopora and the effect of anthelmintics. Molecular and Biochemical Parasitology 11, 205-213 (1984). 2.Balgi, A.D.,Fonseca, B.D.,Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4(9), 1-15 (2009). 3.Ren, X.,Duan, L.,He, Q., et al. Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Med.Chem.Lett. (2010). 4.Tao, H.,Zhang, Y.,Zeng, X., et al. Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nature Medicine 20(11), 1263-1269 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.2 |
| 分子式 | C13H8Cl2N2O4 • C2H7NO |
| CAS号 | 1420-04-8 |
| 稳定性 | ≥ 2 years |
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