| 货号 | 582251-480Well |
| 描述 | Estradiol (17β-estradiol) is the major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female genotype in embryogenesis and at puberty. In addition, estradiol is an important luteolytic agent in humans.1 Estradiol is synthesized from testosterone primarily in the ovarian granulosa cells and placenta, but small amounts can be produced in the adrenal gland.2,3 The conversion of testosterone to estradiol is accomplished by the aromatase system, which consists of 3 enzyme activities localized to the endoplasmic reticulum of the cells in these tissues.1,4 Plasma estradiol levels increase gradually between days 1-7 of the menstrual cycle followed by a sharp increase to a peak value of about 300 pg/ml on day 12 just prior to ovulation.1,5 Estradiol levels in most rodent samples are extremely low, rising to detectable levels only during the pro-estrus period and in pregnant females. |
| 别名 | Estradiol EIA Kit;E2;β-Estradiol;17β-Estradiol;17β-Oestradiol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Erickson, G.F. The ovary: Basic principles and concepts. A. Physiology. Endocrinology and Metabolism 3rd ed., 973-1015 (1995). 2.Naka, M.,Mais, D.E.,Morinelli, T.A., et al. 7-[(1R,2S,3S,5R)-6,6-Dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: A novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. Journal of Pharmacology and Experimental Therapeutics 262, 632-637 (1992). 3.Miller, W.L. and Tyrrell, J.B. The adrenal cortex. Endocrinology and Metabolism 3rd edition, 555-711 (1995). 4.Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988). 5.Munro, C.J.,Stabenfeldt, G.H.,Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clinical Chemistry 37, 838-844 (1991). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 1 year |
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