BPIQ-II (hydrochloride)
货号：
17226-5mg 基本售价：
9702.0 元 规格：
5 mg
产品信息
概述| 货号 | 17226-5mg |
| 描述 | BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).1 It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.1 |
| 别名 | PD 158294; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rewcastle, G.W.,Palmer, B.D.,Bridges, A.J., et al. Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor. Journal of Medicinal Chemistry 39(4), 918-928 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 376.6 |
| 分子式 | C15H10BrN5 • HCl |
| CAS号 | 171179-37-6 |
| 稳定性 | ≥ 2 years |
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